Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isobutyl iodide → 2-chloro-N-isobutyl-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isobutyl iodide | HCID 10556 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide | HCID 67439913 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 2-chloro-N-isobutyl-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide | HCID 25234387 | — |
반응 단계
In analogy to example 10, step 3, 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide (example 10, step 2) was reacted with 1-iodo-2-methylpropane and cesium carbonate in N,N-dimethylacetamide to give 2-chloro-N-isobutyl-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide as a colorless solid. MS: 499.0 ([M+H]+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039493B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-96a985abf37b495894b6939eaa86b7ea |
| 출처 메모 | uspto-grants-2011_10 |