Ethyl orthoformate → 3-(4-Nitrophenyl)-1,2,4-oxadiazole

HRID 1665618노트

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HRID 1665618 반응식
[CH:1](OCC)(OCC)OCC.[OH:11][NH:12][C:13](=[NH:23])[C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=1>C1COCC1>[N+:20]([C:17]1[CH:16]=[CH:15][C:14]([C:13]2[N:23]=[CH:1][O:11][N:12]=2)=[CH:19][CH:18]=1)([O-:22])=[O:21]

참가 물질

4

반응물 2

HCID 31214Ethyl orthoformateHCID 178513348HCID 178513348, 화합물

생성물 1

HCID 27982883-(4-Nitrophenyl)-1,2,4-oxadiazole수율 55%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

Triethyl orthoformate (2.93 g, 19.8 mmol) was added to a stirred solution of N-hydroxy-4-nitro-benzamidine (1.2 g, 6.6 mmol) in THF (15 mL). The mixture was cooled to 0° C. and boron triflouride dimethyl ether (900 mg, 7.9 mmol) was added drop wise. The mixture was maintained at room temperature for three hours. The volatiles were evaporated and the residue was washed with ether and dried to afford 650 mg (55%) of 3-(4-nitro-phenyl)-[1,2,4]oxadiazole.

후처리

  1. temperatureThe mixture was maintained at room temperature for three hours
  2. customThe volatiles were evaporated
  3. washthe residue was washed with ether
  4. customdried

출처 및 근거

ORD 기록
ord-f152925894374548be7a82e0028f655e
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039463B2

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