Hydrochloric Acid → 1-(3-Fluorobenzoyl)piperazine hydrochloride

HRID 1665664

반응식

HRID 1665664 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[F:21][C:17]1[CH:16]=[C:15]([C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[O:22])[CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 578758094-(3-Fluoro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 545927941-(3-Fluorobenzoyl)piperazine hydrochloride수율 89%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A cold solution of 4-(3-fluoro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (400 mg, 1.29 mmol) in 1,4-dioxane.HCl (1 mL) was stirred at 0° C. for 1 hour. The reaction mixture was then concentrated under reduced pressure and the resulting crude residue was washed with ether and dried to afford 280 mg (89%) of (3-fluoro-phenyl)-piperazin-1-yl-methanone.hydrochloride.

후처리

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. washthe resulting crude residue was washed with ether
  3. customdried

출처 및 근거

ORD 기록
ord-b06d171eef854b5f99d89c4b917b89e0
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039463B2

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