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1,1-Dimethoxyethyl(dimethyl)amine → (E)-1-(dimethylamino)ethylidenethiourea

HRID 1666247
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HRID 1666247 반응식
CO[C:3](OC)([N:5]([CH3:7])[CH3:6])[CH3:4].[NH2:10][C:11]([NH2:13])=[S:12]>C(Cl)Cl>[NH2:10][C:11](/[N:13]=[C:3](/[N:5]([CH3:7])[CH3:6])\[CH3:4])=[S:12]
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참가 물질

4

반응물 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 2723790Thiourea

생성물 1

HCID 10654343(E)-1-(dimethylamino)ethylidenethiourea수율 76.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N,N-Dimethyl acetamide dimethyl acetal (75 g, 0.56 mole) was added to a suspension of thiourea (33.0 g, 0.43 mole) in methylene chloride. The mixture was heated under reflux for 4 h. The solvent was removed and the residue was crystallized from 5% MeOH and diethyl ether affording (1E)-N′-(aminocarbonothioyl)-N,N-dimethylethanimidamide (47.8 g, 76% yield).

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 4 h
  3. customThe solvent was removed
  4. customthe residue was crystallized from 5% MeOH and diethyl ether

출처 및 근거

ORD 기록
ord-955c7a9935f041ab95c2b832f1d08e61
출처 데이터셋
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08044062B2

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