[4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol → 4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde

HRID 1666253노트

반응식

HRID 1666253 반응식
[CH2:1]([NH:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([CH3:12])[N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[CH2:1]([NH:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([CH3:12])[N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 57606985[4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol

생성물 1

HCID 576069534-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde수율 93.6%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매2회HCID 6212Chloroform용매

실험 절차

To a solution of [4-(ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol (41.0 g) in chloroform (4000 mL) was added manganese oxide (125 g, 1.4 mole) and stirred for 4 h at room temperature. More manganese oxide was added until the disappearance of alcohol compound was observed. The reaction mixture was filtered through Celite and washed with some chloroform and evaporated all organic solvents to give 38 g (92% yield) of 4-(ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde as a colorless solid, which was used without purification in the next step.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with some chloroform
  3. customevaporated all organic solvents

출처 및 근거

ORD 기록
ord-4f934987f5124f18b77249a762386bb5
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044062B2

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