Thionyl Chloride → 4-Isopropoxy-3-methyl-benzoyl chloride

HRID 1666595노트

반응식

HRID 1666595 반응식
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][C:6]=1[CH3:14])([CH3:3])[CH3:2].S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:17])=[O:10])=[CH:7][C:6]=1[CH3:14])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 592729354-Isopropoxy-3-methylbenzoic acid

생성물 1

HCID 874026094-Isopropoxy-3-methyl-benzoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 4-isopropoxy-3-methyl-benzoic acid (1.35 g, 6.95 mmol) in chloroform (20 mL), thionylchloride (2.48 g, 20.9 mmol) is added. The mixture is refluxed for 2 h before the solvents are removed in vacuo to give crude 4-isopropoxy-3-methyl-benzoic acid chloride; LC-MS: tR=1.00 min.

후처리

  1. temperatureThe mixture is refluxed for 2 h before the solvents
  2. customare removed in vacuo

출처 및 근거

ORD 기록
ord-3dd2f232704e4f738e15288e82bcbccd
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044076B2

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