Hydrochloric Acid → 2-oxo-2-(5-phenoxy-1H-indol-3-yl)acetamide

HRID 1666832노트

반응식

HRID 1666832 반응식
[O:1]=[C:2]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:13]=2)[NH:8][CH:7]=1)[C:3](Cl)=[O:4].[OH-].[NH4+:23].Cl>>[O:1]=[C:2]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:13]=2)[NH:8][CH:7]=1)[C:3]([NH2:23])=[O:4]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 210714422-Oxo-(5-phenoxy-1H-indol-3-yl)acetyl chloride

생성물 1

HCID 210714372-oxo-2-(5-phenoxy-1H-indol-3-yl)acetamide수율 96.4%

실험 절차

Combine 2-oxo-(5-phenoxy-1H-indol-3-yl)acetyl chloride (2.15 g, 7.18 mmol), and ammonium hydroxide (28-30%, 32 ml, 680 mmol) and stir for 2 hours. Pour the reaction mixture into 10% (aq.) HCl, extract with dichloromethane, combine the organic layers and dry over Na2SO4, evaporate solvent in vacuo to give 1.94 g (96%) of title compound: 1H NMR (300 MHz, CDCl3) 4.87 (s, 2H), 7.51-7.91 (m, 7H), 8.13-8.24 (m, 3H).

후처리

  1. extractionextract with dichloromethane
  2. dry with materialdry over Na2SO4
  3. customevaporate solvent in vacuo

출처 및 근거

ORD 기록
ord-cd9d4d3b7d3b46ed8c0ae48e1086a19f
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044090B2

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