1-Methylpiperazine → Olanzapine

HRID 1666930

반응식

HRID 1666930 반응식
[NH2:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[NH:4][C:5]1[S:6][C:7]([CH3:12])=[CH:8][C:9]=1[C:10]#[N:11].[CH3:17][N:18]1[CH2:23][CH2:22]N[CH2:20][CH2:19]1>>[CH3:12][C:7]1[S:6][C:5]2[NH:4][C:3]3[CH:13]=[CH:14][CH:15]=[CH:16][C:2]=3[N:1]=[C:10]([N:11]3[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]3)[C:9]=2[CH:8]=1

참가 물질

3

반응물 2

HCID 531671-Methylpiperazine2회HCID 674452622-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile

생성물 1

HCID 135398745Olanzapine

실험 절차

The process disclosed herein comprises reaction of 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile [10] with N-methylpiperazine in conjunction with N-methyl piperazine acid salt to give Olanzapine. The reaction is carried out at 90-138° C., preferably at 110-125° C. in 6-12 hours.

출처 및 근거

ORD 기록
ord-5e13e6863e2544d6bf3dbc3514595fe8
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044196B2

연결된 노트

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