홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium cyanoborohydride → 3,3-diphenyl-1-{2-[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethyl}pyrrolidin-2-one

HRID 1667140
노트
인쇄 미리보기

반응식

HRID 1667140 반응식
Cl.[F:2][C:3]([F:15])([F:14])[C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][NH:10][CH2:11]2)=[CH:6][CH:5]=1.[O:16]=[C:17]1[C:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:20][CH2:19][N:18]1[CH2:34][CH:35]=O.C([BH3-])#N.[Na+]>CO>[C:28]1([C:21]2([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:20][CH2:19][N:18]([CH2:34][CH2:35][N:10]3[CH2:9][CH2:8][C:7]4[C:12](=[CH:13][C:4]([C:3]([F:2])([F:14])[F:15])=[CH:5][CH:6]=4)[CH2:11]3)[C:17]2=[O:16])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5003444Sodium cyanoborohydrideHCID 441182867-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 866408362-(2-Oxo-3,3-diphenylpyrrolidin-1-yl)acetaldehyde

생성물 1

HCID 674446003,3-diphenyl-1-{2-[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]ethyl}pyrrolidin-2-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (0.153 g, 0.644 mmol), the product from Example 67B (0.120 g, 0.430 mmol) and sodium cyanoborohydride (0.040 g, 0.644 mmol) were stirred together in methanol (0.5 mL) at room temperature. After stirring overnight, the reaction was concentrated, dissolved in minimal dichloromethane and was loaded directly onto a SF15-12 column (Analogix®, Burlington, Wis.), and the title compound was eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (flow=30 mL/minute). 1H NMR (300 MHz, CDCl3) δ ppm 7.36-7.42 (m, 1H), 7.29-7.34 (m, 4H), 7.18-7.26 (m, 2H), 7.12-7.18 (m, 6H), 3.66 (s, 2H), 3.63 (t, J=6.2 Hz, 2H), 3.44 (t, J=6.4 Hz, 2H), 2.69-2.84 (m, 8H); MS (ESI+) m/z 465 (M+H)+.

후처리

  1. concentrationthe reaction was concentrated
  2. dissolutiondissolved in minimal dichloromethane
  3. washthe title compound was eluted
  4. customover 20 minutes

출처 및 근거

ORD 기록
ord-231691fe3e61481dbcaac379e093633a
출처 데이터셋
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08044069B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트