반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH2:12][CH2:11][N:10]([CH2:13][C:14]([OH:16])=O)[C:9]2=[O:17])=[CH:4][CH:3]=1.O=C1C(C2C=CC=CC=2)(C2C=CC=CC=2)CCN1CC(O)=O.[NH2:47][C:48]1[CH:55]=[CH:54][C:51]([C:52]#[N:53])=[CH:50][N:49]=1.FC(F)(F)C1C=CC(N)=NC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)[CH2:12][CH2:11][N:10]([CH2:13][C:14]([NH:47][C:48]3[CH:55]=[CH:54][C:51]([C:52]#[N:53])=[CH:50][N:49]=3)=[O:16])[C:9]2=[O:17])=[CH:4][CH:3]=1참가 물질
5
반응물 4
생성물 1
실험 절차
The title compound was prepared using the procedure described in Example 246 substituting 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 58D for 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid and 6-aminonicotinonitrile for 5-(trifluoromethyl)pyridin-2-amine. 1H NMR (300 MHz, CDCl3) δ ppm 8.55 (s, 2H), 8.25 (d, J=8.7, 1H), 7.93 (dd, J=2.1, 8.7, 1H), 7.43-7.22 (m, 4H), 7.07-6.98 (m, 4H), 4.21 (s, 2H), 3.55 (t, J=6.5, 2H), 2.83 (t, J=6.5, 2H); MS (DCI) m/z 433.0 (M+H)+.
출처 및 근거
- ORD 기록
- ord-d01a9d3dccf0496184c5dc39a3c01f87
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08044069B2
연결된 노트
불러오는 중…