L-Phenylglycine → Tert-butyl (2s)-{[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2h)-yl}phenyl)ethyl]amino}(phenyl)ethanoate

HRID 1667383

반응식

HRID 1667383 반응식
[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15]OS(C)(=O)=O)=[CH:10][CH:9]=2)[C:6](=[O:21])[CH:5]=[CH:4][C:3]=1[C:22](=[O:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1.[CH:31]1[CH:36]=[CH:35][C:34]([C@H:37]([NH2:41])[C:38]([OH:40])=[O:39])=[CH:33][CH:32]=1>>[NH2:1][C:2]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][NH:41][C@@H:37]([C:34]3[CH:33]=[CH:32][CH:31]=[CH:36][CH:35]=3)[C:38]([O:40][C:3]([CH3:22])([CH3:4])[CH3:2])=[O:39])=[CH:12][CH:13]=2)[C:6](=[O:21])[CH:5]=[CH:4][C:3]=1[C:22]([C:23]1[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=1)=[O:30]

참가 물질

3

반응물 2

HCID 99291L-PhenylglycineHCID 58608538Methanesulfonic acid 2-{4-[6-amino-5-(4-fluoro-benzoyl)-2-oxo-2H-pyridin-1-yl]-phenyl}-ethyl ester

생성물 1

HCID 57658465Tert-butyl (2s)-{[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2h)-yl}phenyl)ethyl]amino}(phenyl)ethanoate

실험 절차

From Intermediate 4J and L-Phenylglycine tbutyl ester. LC/MS: m/z 542 [M+H]+. 1H NMR (300 MHz, CDCl3) δ: 10.30 (1H, br s), 7.51-7.45 (3H, m), 7.38 (2H, d, J=6.9 Hz), 7.27-7.04 (9H, m), 5.82 (1H, d, J=9.6 Hz), 4.20 (1H, s), 2.86-2.75 (4H, m), 2.04 (1H, br s), 1.31 (9H, s).

출처 및 근거

ORD 기록
ord-1e827f433fd549eb9b02387ade5be87f
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044211B2

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