N-(3-Cyano-4-(ethylsulfonyl)phenyl)acetamide → N-(3-(Aminomethyl)-4-(ethylsulfonyl)phenyl)acetamide
반응식
[C:1]([C:3]1[CH:4]=[C:5]([NH:14][C:15](=[O:17])[CH3:16])[CH:6]=[CH:7][C:8]=1[S:9]([CH2:12][CH3:13])(=[O:11])=[O:10])#[N:2]>CO.[Ni]>[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([NH:14][C:15](=[O:17])[CH3:16])[CH:6]=[CH:7][C:8]=1[S:9]([CH2:12][CH3:13])(=[O:11])=[O:10]참가 물질
4
실험 절차
To 5C (423 mg, 1.65 mmol) in MeOH (17 mL), Raney Ni (cat) was added. The mixture was stirred under hydrogen (60 psi) for 8 h, then filtered and concentrated to provide 5D (397 mg, 92%). LC-MS: 253.23 (M+H)+.
후처리
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-8077cd3d37524dee9a4260f1c487a12c
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08044242B2
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