Potassium thiocyanate → 2-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl thiocyanate
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[S-:15][C:16]#[N:17].[K+]>C(O)C>[S:15]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4])[C:16]#[N:17]참가 물질
4
실험 절차
A mixture of 10.17 g (36.83 mmole) of 2-bromo-1-(3-trifluoromethyl-phenyl)-ethanone, 4.07 g (41.98 mmole) of potassium thiocyanate and ethanol was heated at reflux for 2 hours. The cooled mixture was concentrated under reduced pressure. The residue was taken up in 225 mL of ethyl acetate, washed three times with 50 mL of water, then 50 mL of brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 8.85 g of 2-thiocyanato-1-(3-trifluoromethyl-phenyl)-ethanone.
후처리
- temperaturewas heated
- temperatureat reflux for 2 hours
- concentrationThe cooled mixture was concentrated under reduced pressure
- washwashed three times with 50 mL of water
- dry with material50 mL of brine, dried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-466333d98a5a42f2bc4e140cf90f86fd
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08044213B2
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