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Ethanol → HCID 59239814, 화합물

HRID 1668380
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인쇄 미리보기

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HRID 1668380 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([C:13]([O:15]C)=O)=[C:10]([N:17]=[CH:18][N:19]([CH3:21])C)[CH:9]=2)=[CH:4][CH:3]=1.Cl.Cl.[N:24]1([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([CH2:36]CN)=[CH:32][CH:31]=2)[CH2:28][CH2:27][CH2:26][CH2:25]1.C(N(CC)C(C)C)(C)C.C(O)C>C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:12][C:11]3[C:13](=[O:15])[N:19]([CH2:21][CH2:36][C:33]4[CH:32]=[CH:31][C:30]([CH2:29][N:24]5[CH2:28][CH2:27][CH2:26][CH2:25]5)=[CH:35][CH:34]=4)[CH:18]=[N:17][C:10]=3[CH:9]=2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 702EthanolHCID 81531DiisopropylethylamineHCID 11544322Methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylateHCID 67360951HCID 67360951, 화합물

생성물 1

HCID 59239814HCID 59239814, 화합물수율 60.9%

시약·촉매·용매 1

HCID 8857
Ethyl Acetate
용매

실험 절차

A mixture of methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate (0.2 g), 2-[4-(pyrrolidin-1-ylmethyl)phenyl]ethanamine dihydrochloride (0.17 g), N,N-diisopropylethylamine (0.20 g) and ethanol (4 ml) was heated under reflux overnight. The reaction mixture was allowed to cool, ethyl acetate was added, and the precipitate was collected by filtration to give the title compound (168 mg) as a colorless powder.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. temperatureto cool
  4. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-6a32c96ffcd94d94915c9c7f8c48fbc4
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989445B2

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