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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → (2s,5r)-5-Allyl-1-[(s)-2-((s)-2-dimethylamino-propionylamino)-pent-4-enoyl]-pyrrolidine-2-carboxylic acid phenethyl-amide

HRID 1668425
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HRID 1668425 반응식
[N:1]([C:8](OC(C)(C)C)=O)([CH3:7])[C@H:2]([C:4](O)=[O:5])[CH3:3].CCN=C=NCCCN(C)C.[CH2:26]([NH:34][C:35]([C@@H:37]1[CH2:41][CH2:40][C@H:39]([CH2:42][CH:43]=[CH2:44])[N:38]1[C:45](=[O:51])[C@@H:46]([NH2:50])[CH2:47][CH:48]=[CH2:49])=[O:36])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>ClCCl.CN(C1C=CN=CC=1)C>[CH2:26]([NH:34][C:35]([C@@H:37]1[CH2:41][CH2:40][C@H:39]([CH2:42][CH:43]=[CH2:44])[N:38]1[C:45](=[O:51])[C@@H:46]([NH:50][C:4](=[O:5])[C@@H:2]([N:1]([CH3:8])[CH3:7])[CH3:3])[CH2:47][CH:48]=[CH2:49])=[O:36])[CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 7009590(2S)-2-(((tert-butoxy)carbonyl)(methyl)amino)propanoic acidHCID 57612851(2S,5R)-5-Allyl-1-((S)-2-amino-pent-4-enoyl)-pyrrolidine-2-carboxylic acid phenethyl-amide

생성물 1

HCID 66994769(2s,5r)-5-Allyl-1-[(s)-2-((s)-2-dimethylamino-propionylamino)-pent-4-enoyl]-pyrrolidine-2-carboxylic acid phenethyl-amide

시약·촉매·용매 2

HCID 14284
4-(Dimethylamino)pyridine
촉매
HCID 6344Dichloromethane용매2회

실험 절차

Boc-N-MeAlaOH (5.36 g, 26.4 mmol) is suspended in dichloromethane (200 mL) and EDCI (5.4 g, 28 mmol) and DMAP (3.4 g, 28 mmol) are added to obtain a clear solution. 11G in dichloromethane (50 mL) is added and stirred overnight followed by quenching with saturated bicarb and extracting with dichloromethane then washing with brine, drying over anhydrous magnesium sulfate, filtering and concentrating. LCMS characterization ES+541.2 (m+1).

후처리

  1. customto obtain a clear solution
  2. customby quenching with saturated bicarb
  3. extractionextracting with dichloromethane
  4. washthen washing with brine
  5. dry with materialdrying over anhydrous magnesium sulfate
  6. filtrationfiltering
  7. concentrationconcentrating

출처 및 근거

ORD 기록
ord-6425ddb72f4c4809a4f758072192fe84
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07989441B2

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