Ethanol → HCID 57825009, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](F)[CH:9]=1)[C:5]#[N:6].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[CH2:21]([OH:23])[CH3:22]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:23][CH2:21][CH3:22])[CH:9]=1)[C:5]#[N:6]

참가 물질

반응물 3

HCID 702Ethanol

HCID 2724254Sodium bis(trimethylsilyl)amide

HCID 27833303-Bromo-5-fluorobenzonitrile

생성물 1

HCID 57825009HCID 57825009, 화합물수율 44%

실험 절차

In analogy to the procedure described in WO2007060448, the reaction of 3-bromo-5-fluorobenzonitrile with ethanol using sodium bis(trimethylsilyl)amide as the base yielded the title compound as a light brown oil (yield: 44% of theory).

출처 및 근거

ORD 기록: ord-f353914028b74196adb91a967c5e4f17
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07989449B2

반응 노트

불러오는 중…