4'-Hydroxypropiophenone → HCID 86085445, 화합물

HRID 1669247

반응식

HRID 1669247 반응식
[OH-].[Na+].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:13])[CH2:11][CH3:12])=[CH:6][CH:5]=1.Cl[CH2:15][C:16]1[C:17]([CH3:25])=[C:18]([CH3:24])[CH:19]=[C:20]([CH3:23])[C:21]=1[CH3:22]>CCO.O>[CH3:22][C:21]1[C:20]([CH3:23])=[CH:19][C:18]([CH3:24])=[C:17]([CH3:25])[C:16]=1[CH2:15][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10](=[O:13])[CH2:11][CH3:12])=[CH:8][CH:9]=1

참가 물질

6

반응물 3

HCID 62714'-HydroxypropiophenoneHCID 14798Sodium HydroxideHCID 819393-(Chloromethyl)-1,2,4,5-tetramethylbenzene

생성물 1

HCID 86085445HCID 86085445, 화합물수율 67.5%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

NaOH (1.6 g, 40 mmol) is added to the solution of 1-(4-hydroxy-phenyl)-propan-1-one (3.0 g, 20 mmol) in EtOH (50 mL) and water (30 mL), followed by the addition of 3-Chloromethyl-1,2,4,5-tetramethyl-benzene (5.5 g, 30 mol). The resulting mixture is heated to turn into clear solution and stirred at room temperature overnight. The reaction is quenched by 1N HCl and extracted with ethyl acetate (3×100 mL). The combined organic layers are washed with water, brine, dried (MgSO4), concentrated and chromatographed to afford the titled compound as a white solid (4.0 g).

후처리

  1. temperatureThe resulting mixture is heated
  2. customThe reaction is quenched by 1N HCl
  3. extractionextracted with ethyl acetate (3×100 mL)
  4. washThe combined organic layers are washed with water, brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated
  7. customchromatographed

출처 및 근거

ORD 기록
ord-c3a58e85ffe24f79bd6fe328aa87a9f6
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989457B2

연결된 노트

불러오는 중…