Sodium borohydride → 1-(4'-Trifluoromethyl-biphenyl-4-yl)-butan-2-ol

HRID 1669289노트

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HRID 1669289 반응식
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16](=[O:19])[CH2:17][CH3:18])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[BH4-].[Na+]>C(O)C>[F:1][C:2]([F:20])([F:21])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([OH:19])[CH2:17][CH3:18])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 673416551-(4'-Trifluoromethyl-biphenyl-4-yl)-butan-2-one

생성물 1

HCID 673421621-(4'-Trifluoromethyl-biphenyl-4-yl)-butan-2-ol수율 94%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
0 °C

실험 절차

To an ethanol (2 mL) solution of 1-(4′-trifluoromethyl-biphenyl-4-yl)-butan-2-one (0.093 g, 0.32 mmol) is added sodium borohydride (0.048 g, 1.27 mmol) at 0° C. The reaction mixture is stirred one hour at 0° C., quenched by saturated sodium bicarbonate solution (1 mL) and stirred for five minutes, extracted with ethyl acetate. Organic phase is washed with saturated sodium bicarbonate and brine dried over sodium sulfate, filtered and concentrated to give 0.088 g (0.30 mmol, 94%) of title compound.

후처리

  1. customquenched by saturated sodium bicarbonate solution (1 mL)
  2. stirringstirred for five minutes
  3. extractionextracted with ethyl acetate
  4. washOrganic phase is washed with saturated sodium bicarbonate and brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ba3e0d99e1374258a89fd36e1f9329ea
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989457B2

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