Hydrochloric Acid → 3-(2-Cyanoethyl)benzaldehyde

HRID 1669355노트

반응식

HRID 1669355 반응식
[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]2OCC[O:12]2)[CH:8]=[CH:9][CH:10]=1)#[N:2].Cl>O1CCCC1>[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[CH:11]=[O:12])#[N:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 231317192-[3-(2-Cyanoethyl)phenyl]-[1,3]dioxolane

생성물 1

HCID 114992593-(2-Cyanoethyl)benzaldehyde수율 97.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 3.52 g of 2-[3-(2-cyanoethyl)phenyl]-[1,3]dioxolane was added 60 ml of tetrahydrofuran to dissolve this, and 20 ml of 6 N hydrochloric acid was added. After stirred at room temperature overnight and then concentrated under reduced pressure, ethyl acetate was added, and this was washed successively with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution. After dried over anhydrous magnesium sulfate, concentration under reduced pressure afforded 2.68 g of 3-(2-cyanoethyl)benzaldehyde [Compound No. (m)].

후처리

  1. additionwas added
  2. concentrationconcentrated under reduced pressure, ethyl acetate
  3. additionwas added
  4. washthis was washed successively with an aqueous potassium carbonate solution
  5. dry with materialAfter dried over anhydrous magnesium sulfate, concentration under reduced pressure

출처 및 근거

ORD 기록
ord-90734633cab14b5097d58ef503e44dba
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989478B2

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