Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Cresol → 1-(Methoxymethoxy)-2-methylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Cresol | HCID 335 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | DMF ether | HCID 19966313 | — |
| 생성물 | 1-(Methoxymethoxy)-2-methylbenzene | HCID 3839351 | — |
반응 단계
To a suspension of NaH (60% dispersion in mineral oil; 1.2 eq) in Et2O/DMF (5:1, 0.2M) a solution of o-cresol in Et2O (1 eq, 2M) was added dropwise over 15 min. A solution of MOMCl in Et2O (1.1 eq, 2M) was added and the mixture was stirred for 30 min then poured into H2O and extracted with Et2O. The combined organic extracts were washed with 1N NaOH, H2O and brine, dried over Na2SO4, filtered and evaporated in vacuo to give the title compound. The product was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07989438B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-20b43335f7ed4d1abe3450533abe617c |
| 출처 메모 | uspto-grants-2011_08 |