Benzamide → HCID 178487733, 화합물

반응식

[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[C:14]([NH2:22])(=O)[C:15]1[CH:20]=[CH:19][CH:18]=C[CH:16]=1.Cl.C(Cl)C1C=CC=NC=1>>[CH3:13][O:12][C:9]1[C:10]([CH3:11])=[C:2]2[C:3]([C:4]([OH:5])=[N:6][C:16]([C:15]3[CH:14]=[N:22][CH:18]=[CH:19][CH:20]=3)=[N:1]2)=[CH:7][CH:8]=1

참가 물질

반응물 3

HCID 2331Benzamide

HCID 233943-(Chloromethyl)pyridine hydrochloride

HCID 591654352-Amino-4-methoxy-3-methylbenzamide

생성물 1

HCID 178487733HCID 178487733, 화합물수율 92%

실험 절차

The general procedure described in Example 31 was followed using 2-amino-4-methoxy-3-methyl benzamide as benzamide derivative and nicotinyl chloride hydrochloride as acid chloride, which gave the title compound (2.5 g, 92%), [M+H]=268.

출처 및 근거

ORD 기록: ord-bfbd15fa72d24102989e584d4914a787
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07989471B2

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