Methanol → HCID 17786435, 화합물
반응식
[N:1]([CH:4]([C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)[CH2:5][CH3:6])=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CO>C1COCC1.O>[N:8]1[CH:9]=[CH:10][N:11]=[CH:12][C:7]=1[CH:4]([NH2:1])[CH2:5][CH3:6]참가 물질
6
반응 조건
- 온도
- 50 °C
실험 절차
The 2-(1-azidopropyl)pyrazine (56 mg) was dissolved in the THF (5 ml) and water (1 ml) and the PS-PPh3 (225 mg) added. The reaction mixture was heated to 50° C. and left to stir for approx. 20 hours. The mixture was filtered under vacuum and rinsed with DCM (a precipitate formed and re-dissolved with MeOH) then MeOH. The filtrate was evaporated to yield the title compound as a yellow oil which was used without further purification. [M+H]+ 138.
후처리
- waitleft
- filtrationThe mixture was filtered under vacuum
- washrinsed with DCM (a precipitate
- customformed
- customThe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-31721223934b4766b4e41bae6e1fb069
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07989497B2
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