Methyl morpholine oxide → 5-Chloro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde

HRID 1669778노트

반응식

HRID 1669778 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([CH:12](Br)Br)=[C:8]2[C:3]=1[C:4](=[O:16])[CH:5]=[C:6]([CH3:15])[O:7]2.C[N+]1([O-])CC[O:21]CC1>C(#N)C>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([CH:12]=[O:21])=[C:8]2[C:3]=1[C:4](=[O:16])[CH:5]=[C:6]([CH3:15])[O:7]2

참가 물질

4

반응물 2

HCID 82029Methyl morpholine oxideHCID 574388935-chloro-8-(dibromomethyl)-2-methyl-4H-chromen-4-one

생성물 1

HCID 574388945-Chloro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

210 mg (0.57 mmol) of 5-chloro-8-(dibromomethyl)-2-methyl-4H-chromen-4-one are heated with 147 mg (1.2 mmol) of N-methylmorpholine N-oxide with the addition of molecular sieves in 15 ml of acetonitrile under reflux overnight. After filtration through kieselguhr, the solvent is removed in vacuo and the residue is purified by preparative HPLC. 22 mg (17% of theory) of the title compound are obtained.

후처리

  1. temperatureunder reflux overnight
  2. filtrationAfter filtration through kieselguhr
  3. customthe solvent is removed in vacuo
  4. customthe residue is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-61f0625179394896a07f395e4e343a5d
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989633B2

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