3-Methyl-5-(4-methylphenyl)isoxazole → 3-Amino-1-(4-methylphenyl)but-2-en-1-one

HRID 1669801노트

반응식

HRID 1669801 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[O:4][N:3]=1>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=1)=[O:4]

참가 물질

4

반응물 1

HCID 103521723-Methyl-5-(4-methylphenyl)isoxazole

생성물 1

HCID 673437903-Amino-1-(4-methylphenyl)but-2-en-1-one

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

3-Methyl-5-(4-methylphenyl)isoxazole (1 g, 5.77 mmol) is introduced into 20 ml of ethanol, platinum(IV) oxide catalyst (100 mg) is added, and the mixture is then hydrogenated under atmospheric hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 1.02 g (100% of theory) of the title compound are obtained as a white solid.

후처리

  1. additionis added
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated

출처 및 근거

ORD 기록
ord-27a6cf0c335441e7ac03812465a2a108
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989633B2

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