5-(4-Fluorophenyl)-3-methyl-1,2-oxazole → HCID 67342452, 화합물
반응식
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[O:4][N:3]=1.[H][H]>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)=[O:4]참가 물질
5
실험 절차
3-Methyl-5-(4-fluorophenyl)isoxazole (620 mg, 3.49 mmol) is introduced into 16 ml of ethanol, platinum(IV) oxide catalyst (62 mg) is added, and the mixture is then hydrogenated under atmospheric pressure hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 573 mg (91% of theory) of the title compound are obtained as a white solid.
후처리
- additionis added
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
출처 및 근거
- ORD 기록
- ord-bc8c514d17cf4445b9a84141324b1a31
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07989633B2
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