Dibenzofuran → 2-Bromodibenzofuran

HRID 1669918

반응식

HRID 1669918 반응식
[Br:1]Br.[CH:3]1[C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.O>C(O)(=O)C>[Br:1][C:4]1[CH:5]=[CH:6][C:7]2[O:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[C:11]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 568DibenzofuranHCID 962WaterHCID 24408Bromine

생성물 1

HCID 68562-Bromodibenzofuran수율 13%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

반응 조건

온도
50 °C

실험 절차

Bromine (23.8 g, 0.156 mol) in acetic acid (5 g) is added at 50° C. to a solution of dibenzofuran (25 g, 0.149 mol) in acetic acid (230 g). The mixture is then stirred at 50° C. for 4 hours. The reaction mixture is cooled to room temperature and poured into H2O. The orange solid is washed with Na2S2O3 aq. and H2O. The crude product is then purified by recrystallization from toluene/CH2Cl2, wherein the pure product is obtained as a white solid (13% yield).

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. washThe orange solid is washed with Na2S2O3 aq. and H2O
  3. customThe crude product is then purified by recrystallization from toluene/CH2Cl2, wherein the pure product

출처 및 근거

ORD 기록
ord-261dee3d83cf4f0a86d5560a33189962
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989644B2

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