Lithium Hydroxide → (2R)-N-methanesulfonyl-(4-chlorophenyl)alanine
반응식
C[O:2][C:3](=[O:18])[C@@H:4]([CH3:17])[N:5]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[S:6]([CH3:9])(=[O:8])=[O:7].[Li+].[OH-]>O.CO>[CH3:9][S:6]([N:5]([C:10]1[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=1)[C@@H:4]([C:3]([OH:18])=[O:2])[CH3:17])(=[O:7])=[O:8]참가 물질
4
실험 절차
To a solution of (2R)-N-methanesulfonyl-(4-chlorophenyl)alanine methylester, prepared in Step A, in water/methanol (5 mL, 1/1) was added portionwise LiOH (70.0 mg, 2.00 mmol). After being stirred at rt for 3 h, the reaction mixture was concentrated, and the residue was diluted with 1N HCl solution. The organic material was extracted with EtOAc, the extracts were concentrated in vacuo to give the title compound (179 mg, 94.3%).
후처리
- concentrationthe reaction mixture was concentrated
- additionthe residue was diluted with 1N HCl solution
- extractionThe organic material was extracted with EtOAc
- concentrationthe extracts were concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-17e24dfe560444e78f5a74562a9c6df4
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07989634B2
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