Sodium Hydroxide → 3-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid

HRID 1670075노트

반응식

HRID 1670075 반응식
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[C:6]([C:18]2[CH:26]=[CH:25][C:21]3[O:22][CH2:23][O:24][C:20]=3[CH:19]=2)[CH:5]=1.[OH-].[Na+]>O1CCOCC1>[O:22]1[C:21]2[CH:25]=[CH:26][C:18]([C:6]3[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH2:11][C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH:7]=3)[C:3]([OH:27])=[O:2])=[CH:19][C:20]=2[O:24][CH2:23]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 579059323-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid Methyl Ester

생성물 1

HCID 579058343-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid수율 97%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

3-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic acid methyl ester (14.2 g) was dissolved in 1,4-dioxane (200 mL) and then 1 M aq. NaOH (40 mL) was added. The mixture was stirred at room temperature overnight. The solvents were removed under reduced pressure and the residue was diluted with water (200 mL). It was then made acidic by addition of 10% HCl (aq.) solution and the precipitated material was collected by filtration. The solid was washed with water and dried to yield 13.2 g (97% yield) of the title compound.

후처리

  1. customThe solvents were removed under reduced pressure
  2. additionthe residue was diluted with water (200 mL)
  3. additionmade acidic by addition of 10% HCl (aq.) solution
  4. filtrationthe precipitated material was collected by filtration
  5. washThe solid was washed with water
  6. customdried

출처 및 근거

ORD 기록
ord-98aa8d1dc14548ef902dbda8b628317c
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989454B2

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