Acetic Anhydride → 4-[3-{6-[3-(4-Acetyl-piperazine-1-carbonyl)-5-benzo[1,3]dioxol-5-yl-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric Acid

HRID 1670078노트

반응식

HRID 1670078 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([CH:38]=[C:39]([C:41]([N:43]4[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]4)=[O:42])[CH:40]=3)[O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:21]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[C:22]([CH:30]=[CH:31][CH:32]=3)[O:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:9][C:4]=2[O:3][CH2:2]1.[C:49](OC(=O)C)(=[O:51])[CH3:50].C(N(CC)CC)C>ClCCl.C(OCC)(=O)C>[C:49]([N:46]1[CH2:45][CH2:44][N:43]([C:41]([C:39]2[CH:38]=[C:12]([CH:11]=[C:10]([C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)[CH:40]=2)[O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]2[C:21]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[C:22]([CH:30]=[CH:31][CH:32]=2)[O:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[O:42])[CH2:48][CH2:47]1)(=[O:51])[CH3:50]

참가 물질

6

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 426303214-[3-{6-[3-Benzo[1,3]dioxol-5-yl-5-(piperazine-1-carbonyl)-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric acid

생성물 1

HCID 673390604-[3-{6-[3-(4-Acetyl-piperazine-1-carbonyl)-5-benzo[1,3]dioxol-5-yl-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric Acid

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

4-[3-{6-[3-Benzo[1,3]dioxol-5-yl-5-(piperazine-1-carbonyl)-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (0.29 mmol), acetic anhydride (1.2 eq.), triethylamine (3 eq.) were combined in dichloromethane (2 mL) and stirred overnight. Then the reaction mixture was diluted with ethyl acetate, washed with water and dried over anhydrous sodium sulfate. The organic extract was concentrated under reduced pressure and purified by reverse-phase HPLC to yield the title compound.

후처리

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. extractionThe organic extract
  4. concentrationwas concentrated under reduced pressure
  5. custompurified by reverse-phase HPLC

출처 및 근거

ORD 기록
ord-56601493fce84ec584e5a8823c8abad4
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989454B2

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