Hydrochloric Acid → 4-(4-Amino-3-fluorophenoxy)pyridin-2-amine

HRID 1670301노트

반응식

HRID 1670301 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15]C(=O)C(C)(C)C)=[C:11]([F:22])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.Cl>CO>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH2:1])[CH:7]=2)=[CH:10][C:11]=1[F:22]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59852964N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide

생성물 1

HCID 71470884-(4-Amino-3-fluorophenoxy)pyridin-2-amine수율 54%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide (70 mg, 0.23 mmol) in 3 mL of MeOH was added 2 mL of 6 N HCl. The mixture was then heated at reflux for 48 h. After cooling down, the solvent was removed under reduced pressure and the residue was purified by solid extraction (Waters Oasis MCX extraction cartridge) to give 4-(4-amino-3-fluorophenoxy)pyridin-2-amine (27 mg, 54% yield). MS (ESI+): m/z 220.21 (M+H)+.

후처리

  1. temperatureThe mixture was then heated
  2. temperatureat reflux for 48 h
  3. temperatureAfter cooling down
  4. customthe solvent was removed under reduced pressure
  5. customthe residue was purified by solid extraction (Waters Oasis MCX extraction cartridge)

출처 및 근거

ORD 기록
ord-e5ecf470d9584b09b020e63669641102
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07989477B2

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