Benzoyl Peroxide → 5-Bromo-2-(bromomethyl)-1,3-dichlorobenzene

HRID 1670810

반응식

HRID 1670810 반응식
[Br:1][C:2]1[CH:3]=[C:4]([Cl:10])[C:5]([CH3:9])=[C:6]([Cl:8])[CH:7]=1.[Br:11]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH2:9][Br:11])=[C:4]([Cl:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 6411555-Bromo-1,3-dichloro-2-methylbenzene

생성물 1

HCID 594744985-Bromo-2-(bromomethyl)-1,3-dichlorobenzene수율 87.8%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

Heat to reflux a solution of 5-bromo-1,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol), N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87%) of the product as white crystals.

후처리

  1. temperatureHeat
  2. temperatureCool
  3. customthe reaction to room temperature
  4. concentrationconcentrate to an orange residue
  5. customPurify the residue by silica gel chromatography
  6. washeluting with hexanes

출처 및 근거

ORD 기록
ord-528fb59ffc1f47bb9b46305a8d127424
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994176B2

연결된 노트

불러오는 중…