Hydrochloric Acid → N-Methoxy-N-methylbenzofuran-5-carboxamide
반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](Cl)=[O:11])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[CH3:13][NH:14][O:15][CH3:16].Cl.C(N(CC)CC)C>C(Cl)Cl>[CH3:16][O:15][N:14]([CH3:13])[C:10]([C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH:2]=[CH:3][C:4]=2[CH:9]=1)=[O:11]참가 물질
6
실험 절차
Benzofuran-5-carbonyl chloride (1 g, 5.54 mmol) in dry DCM (40 ml) is treated with N,O-dimethylhydroxylamine.HCl (0.594 g, 6.09 mmol) followed by triethylamine (1.930 ml, 13.84 mmol). After stirring at RT overnight, the mixture is diluted with DCM and washed with H2O, 1M HCl, 1M NaOH, brine, dried (MgSO4) and evaporated down to give a brown oil which is used without further purification; MS: m/z 206.1 [M+H]+
후처리
- washwashed with H2O, 1M HCl, 1M NaOH, brine
- dry with materialdried (MgSO4)
- customevaporated down
- customto give a brown oil which
- customis used without further purification
출처 및 근거
- ORD 기록
- ord-23367186aafe462faa1f35bddd627338
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07994203B2
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