Methyl pyrimidine-4-carboxylate → 4-Pyrimidinecarboxylic acid

HRID 1671469

반응식

HRID 1671469 반응식
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][N:6]=1)=[O:4].BrC1C(C(O)=S)=NC(C)=NC=1>[Ni]>[N:8]1[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 254248Methyl pyrimidine-4-carboxylateHCID 178432654HCID 178432654, 화합물

생성물 1

HCID 1693064-Pyrimidinecarboxylic acid

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

While J. Org. Chem., 30, 2398 (1965) describes that methylpyrimidine-4-carboxylate can be synthesized by treating 5-bromo-2-methylthiopyrimidine-4-carboxylic acid with Raney-nickel, as described in J. Chem. Soc., 1953, 3129, to give pyrimidine-4-carboxylic acid, and heating the obtained compound in methanol in the presence of concentrated hydrochloric acid. This method is problematic in the availability of the starting materials.

후처리

  1. customcan be synthesized

출처 및 근거

ORD 기록
ord-d5a16c132df441b6816d964009780896
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07994315B2

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