Sodium Hydroxide → (S)-(4-Fluorophenyl)oxirane
반응식
[OH-].[Na+].Cl[CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[OH:6]>C(OCC)C>[F:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[CH2:4][O:6]2)=[CH:8][CH:9]=1참가 물질
4
실험 절차
1.6 M aqueous sodium hydroxide solution (50 ml) was added to a solution of 2-chloro-(1S)-1-(4-fluorophenyl)ethanol (10.4 g) in diethyl ether (40 ml), and the mixture was stirred at room temperature for 5 hrs. The organic layer was separated and the aqueous layer was extracted with diethyl ether. The combined organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give (2S)-2-(4-fluorophenyl)oxirane (8.28 g) as a colorless oil.
후처리
- customThe organic layer was separated
- extractionthe aqueous layer was extracted with diethyl ether
- washThe combined organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-a2c1a25bbfbd460b93acd43a194b2fd2
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US07994315B2
반응 노트
불러오는 중…