HCID 67335596, 화합물 → HCID 67335638, 화합물
반응식
C([O:3][C:4](=O)[CH2:5][NH:6][CH2:7][C:8]1([NH:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)C>Cl>[NH:20]1[C:21]2[C:17](=[CH:16][C:15]([N:14]3[C:8]4([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]4)[CH2:7][NH:6][CH2:5][C:4]3=[O:3])=[CH:23][CH:22]=2)[CH:18]=[N:19]1참가 물질
3
실험 절차
A mixture of {[1-(1H-indazol-5-ylamino)-cyclohexylmethyl]-amino}-acetic acid ethyl ester (0.808 g, 2.45 mmol) in 2N HCl (11 mL) was heated at reflux for 17 hours, then cooled to room temperature and quenched by the careful addition of K2CO3 until no more effervescence was observed. The resulting mixture was extracted with DCM and the combined extracts were dried (MgSO4), filtered and concentrated in vacuo to furnish 1-(1H-indazol-5-yl)-1,4-diaza-spiro[5.5]undecan-2-one (0.350 g, 1.23 mmol, 50%) as a solid that was used directly without further purification.
후처리
- temperaturewas heated
- temperatureat reflux for 17 hours