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N-(2-Chlorophenyl)-6-methoxy-3-nitro-4-quinolinamine → HCID 60046938, 화합물

HRID 1672327
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인쇄 미리보기

반응식

HRID 1672327 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[CH:17]=2)[N:12]=[CH:11][C:10]=1[N+:21]([O-])=O>CO.[Ni]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[CH:17]=2)[N:12]=[CH:11][C:10]=1[NH2:21]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 60046940N-(2-Chlorophenyl)-6-methoxy-3-nitro-4-quinolinamine

생성물 1

HCID 60046938HCID 60046938, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

The title compound is prepared in analogy to Example 19e, starting from 0.8 g (2.4 mmol) of (2-chloro-phenyl)-(6-methoxy-3-nitro-quinolin-4-yl)-amine (Example 44h) and 0.4 g Raney-Ni in 30 ml methanol. Time of hydrogenation: 1 h at rt. Crystallization of the product from ethyl acetate-hexane. mp: 120-123° C.; MS: 300 (M++1); HPLC: tret=8.41 min (Grad 1).

후처리

  1. custom1 h
  2. customat rt
  3. customCrystallization of the product from ethyl acetate-hexane
  4. customtret=8.41 min (Grad 1)

출처 및 근거

ORD 기록
ord-631462b395b845c7821cec9167f6e423
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07998972B2

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