Isobutyraldehyde → 7-(2-Chlorophenyl)-1-isobutyl-1,7-diazaspiro[4.4]nonan-6-one

HRID 1672378노트

반응식

HRID 1672378 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:16][CH2:15][C:10]2([NH:14][CH2:13][CH2:12][CH2:11]2)[C:9]1=[O:17].[CH:18](=O)[CH:19]([CH3:21])[CH3:20].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:16][CH2:15][C:10]2([N:14]([CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:13][CH2:12][CH2:11]2)[C:9]1=[O:17]

참가 물질

5

반응물 3

HCID 6561IsobutyraldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 589483317-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one

생성물 1

HCID 166550297-(2-Chlorophenyl)-1-isobutyl-1,7-diazaspiro[4.4]nonan-6-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

7-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one (20 mg, 0.00008 mol) was dissolved in anhydrous DCM (2 mL). To this mixture was added isobutyraldehyde (8.0 μL, 0.000088 mol) and sodium triacetoxyborohydride (3.0E1 mg, 0.00014 mol). The resulting solution was stirred at RT for 16 h. The volatiles were removed in vacuo and the resulting residue was dissolved in acetonitrile/H2O and purified by prep.-LC/MS chromatography to afford the desired product. LC-MS: 307.1 (M+1H)+.

후처리

  1. customThe volatiles were removed in vacuo
  2. dissolutionthe resulting residue was dissolved in acetonitrile/H2O
  3. custompurified by prep.-LC/MS chromatography

출처 및 근거

ORD 기록
ord-8c5223cd1979476598927ad65121b715
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07998959B2

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