Triphenylphosphonium hydrobromide → Triphenyl[2-(4'-trifluoromethylbiphenyl-4-ylmethoxy)benzyl]phosphonium bromide

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반응 단계

A solution of 11.7 g (32.65 mmol) of [2-(4′-trifluoromethylbiphenyl-4-ylmethoxy)phenyl]-methanol from Example 24A in 100 ml of acetonitrile is mixed with 10.64 g (31.02 mmol) of triphenylphosphonium hydrobromide and heated to reflux for 3 hours. The reaction solution is then concentrated to dryness, and the resulting oil is taken up and triturated in diethyl ether. The product crystallizes as a white solid during this. After filtration, the solid is dried in a oven at 50° C. overnight. 20.5 g (30 mmol, 92% yield) of crystalline product are obtained.

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