HCID 178455336, 화합물 → HCID 178516223, 화합물

HRID 1672725노트

반응식

HRID 1672725 반응식
C([Si](C)(C)[O:6][C@@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]2[CH2:17][CH2:16][CH2:15][C:14]2=[O:18])[CH2:9][CH2:8]1)(C)(C)C>Cl.CCO>[OH:6][C@@H:7]1[CH2:8][CH2:9][C@H:10]([N:13]2[CH2:17][CH2:16][CH2:15][C:14]2=[O:18])[CH2:11][CH2:12]1

참가 물질

4

반응물 1

HCID 178455336HCID 178455336, 화합물

생성물 1

HCID 178516223HCID 178516223, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

Heat a solution of cis-1-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one (500 mg) in 5 mL of 1N HCl in EtOH to 45° C. for 1 h. Cool the mixture to room temp and concentrate. Dissolve the residue in NaHCO3 (10 mL) and CH2Cl2 (10 mL). Extract the aqueous layer two times with 10 mL of CH2Cl2. Dry the organic layer over Na2SO4, filter and concentrate. Purify the crude material by chromatography to yield the title compound: mass spectrum (m/z): 184 (M+1).

후처리

  1. concentrationconcentrate
  2. dissolutionDissolve the residue in NaHCO3 (10 mL)
  3. extractionExtract the aqueous layer two times with 10 mL of CH2Cl2
  4. dry with materialDry the organic layer over Na2SO4
  5. filtrationfilter
  6. concentrationconcentrate
  7. customPurify the crude material by chromatography

출처 및 근거

ORD 기록
ord-000a4b6bd78c49beaf6ba122a6f9a46f
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07998999B2

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