Water → 5-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one

HRID 1672847노트

반응식

HRID 1672847 반응식
[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11](=[O:13])[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:14](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11](=[O:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21071758HCID 21071758, 화합물

생성물 1

HCID 673486545-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one수율 90.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-(3-Iodophenyl)-1,3,4-oxadiazol-2(3H)-one (778 mg, 2.70 mmol) obtained in Step 1 was dissolved in DMF (14 mL), and the mixture was stirred at room temperature for 1 hour after adding potassium carbonate (840 mg, 4.05 mmol) and methyl iodide (0.20 mL, 3.24 mmol). The mixture was stirred after adding water, and the precipitated solid was filtered off and dried to give 5-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one (736 mg, 90%).

후처리

  1. stirringThe mixture was stirred
  2. filtrationthe precipitated solid was filtered off
  3. customdried

출처 및 근거

ORD 기록
ord-ea7a6f97ad6f4354a0d3e8fbb083e0ae
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07998954B2

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