2-chloro-N-(2-phenylethyl)propanamide → HCID 57437916, 화합물
반응식
Cl[CH:2]([CH3:14])[C:3]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[Cl-].[Cl-].[Cl-].[Al+3]>O.CO>[CH3:14][CH:2]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6][NH:5][C:3]1=[O:4]참가 물질
5
반응 조건
- 온도
- 150 °C
실험 절차
8.0 g (37 mmol) 2-chloro-N-(2-phenylethyl)-propanamide and 15 g (112 mmol) aluminium trichloride are carefully mixed at 90° C. and heated to 150° C. for 6 h. The mixture is diluted with water and methanol and extracted with EtOAc. The combined organic phases are dried with Na2SO4, concentrated i. vac. and purified by chromatography.
후처리
- extractionextracted with EtOAc
- dry with materialThe combined organic phases are dried with Na2SO4
- concentrationconcentrated i
- customand purified by chromatography
출처 및 근거
- ORD 기록
- ord-b8e66e1a7fa8451e91c97e6352ae81b8
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003639B2
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