Triethylamine → 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene

HRID 1675308

반응식

HRID 1675308 반응식
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([CH2:14]O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C(N(CC)CC)C.S(Cl)([Cl:27])=O>C(Cl)Cl>[Cl:27][CH2:14][C:12]1[S:13][C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:17])([F:16])[F:1])=[CH:4][CH:5]=2)=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 219863522-Thiophenemethanol, 5-[4-(trifluoromethyl)phenyl]-

생성물 1

HCID 575949792-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 61.3 (45 mg, 0.18 mmol) in DCM (0.9 mL) were added triethylamine (24 μL, 0.18 mmol) and thionyl chloride (19 μL, 0.26 mmol) at room temperature. The mixture was stirred overnight and concentrated to afford 61.4. The crude product was used without further purification.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-770aa0a6ed184a3e9e55631ad9668879
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003648B2

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