Methyl iodide → 1-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl-carbamoyl)-3-methyl-1H-imidazol-3-ium iodide

HRID 1675395노트

반응식

HRID 1675395 반응식
[CH3:1][I:2].[N:3]1([C:8]([NH:10][C@:11]2([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:13][C@H:12]2[CH:14]=[CH2:15])=[O:9])[CH:7]=[CH:6][N:5]=[CH:4]1>C(#N)C>[I-:2].[CH2:19]([O:18][C:16]([C@@:11]1([NH:10][C:8]([N:3]2[CH:7]=[CH:6][N+:5]([CH3:1])=[CH:4]2)=[O:9])[CH2:13][C@H:12]1[CH:14]=[CH2:15])=[O:17])[CH3:20]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 57816680(1R,2S)-ethyl 1-(1H-imidazole-1-carboxamido)-2-vinylcyclopropanecarboxylate

생성물 1

HCID 866332061-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl-carbamoyl)-3-methyl-1H-imidazol-3-ium iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Under nitrogen, methyl iodide (1.9 mL, 4 eq.) was added to a solution of compound 33 (2 g, 1 eq.) in ACN (16 mL). The reaction mixture was stirred at room temperature for 2 hrs. The solvent was removed under reduced pressure to yield compound 34 as yellow oil, which was used directly in the next step without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-d7249a37462846cf819c763a58c5eacd
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003659B2

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