Sodium Hydroxide → 6-Hydroxy-4,4-dimethylhexane-1,2-diyl dinitrate

HRID 1676005노트

반응식

HRID 1676005 반응식
[N+](C1C=CC(C([O:10][CH2:11][CH2:12][C:13]([CH3:26])([CH3:25])[CH2:14][CH:15]([O:21][N+:22]([O-:24])=[O:23])[CH2:16][O:17][N+:18]([O-:20])=[O:19])=O)=CC=1)([O-])=O.[OH-].[Na+]>C1COCC1.CCO.C(=O)(O)[O-].[Na+]>[N+:18]([O-:20])([O:17][CH2:16][CH:15]([O:21][N+:22]([O-:24])=[O:23])[CH2:14][C:13]([CH3:26])([CH3:25])[CH2:12][CH2:11][OH:10])=[O:19]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 582094543,3-Dimethyl-5,6-bis(nitrooxy)hexyl 4-nitrobenzoate

생성물 1

HCID 597787456-Hydroxy-4,4-dimethylhexane-1,2-diyl dinitrate

시약·촉매·용매 2

HCID 516892Sodium Bicarbonate용매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

To a solution of 3,3-dimethyl-5,6-bis(nitrooxy)hexyl 4-nitrobenzoate (1.9 g, 4.73 mmol) in THF:EtOH 1:1 (12 ml) a aqueous solution of NaOH 3N (3.8 ml, 11.4 mmol) was added and the mixture was stirred at room temperature for 3 hrs. Then the mixture was diluted with a saturated solution of sodium bicarbonate and the product was extracted with EtOAc (3×30 ml). The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure, affording the title compound which was used in the subsequent step without further purification.

후처리

  1. extractionthe product was extracted with EtOAc (3×30 ml)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5a7fb8c7b8e348bba5198b718f1aa3a2
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003811B2

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