ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate → 3-(6-Amino-1H-benzimidazol-1-yl)-3-phenylpropanoic acid

HRID 1676020노트

반응식

HRID 1676020 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][C:12]([O:14]CC)=[O:13])[C:6]=2[CH:23]=1>Cl>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[CH:23]=1

참가 물질

3

반응물 1

HCID 67351765ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate

생성물 1

HCID 586536393-(6-Amino-1H-benzimidazol-1-yl)-3-phenylpropanoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of ethyl 3-(6-amino-1H-benzimidazol-1-yl)-3-phenylpropanoate, (25 mg, 81 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 96 hours. The solution was evaporated in vacuo and purified by RP-HPLC to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=2.59 min, MH+ 282].

후처리

  1. customThe solution was evaporated in vacuo
  2. custompurified by RP-HPLC

출처 및 근거

ORD 기록
ord-100eb7402a034d049717dd1721a0c724
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003806B2

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