Acetonitrile → HCID 11682467, 화합물

HRID 1676093노트

반응식

HRID 1676093 반응식
[NH:1]([C:8]([C:10]1[CH:31]=[CH:30][C:13]2[N:14]([CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][C:19]([O:21]CC)=[O:20])[CH:15]=[N:16][C:12]=2[CH:11]=1)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(#N)C>Cl>[NH:1]([C:8]([C:10]1[CH:31]=[CH:30][C:13]2[N:14]([CH:17]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:18][C:19]([OH:21])=[O:20])[CH:15]=[N:16][C:12]=2[CH:11]=1)=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6342AcetonitrileHCID 58653679HCID 58653679, 화합물

생성물 1

HCID 11682467HCID 11682467, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of ethyl 3-[5-(anilinocarbonyl)-1H-benzimidazol-1-yl]-3-phenylpropanoate (27 mg, 65 μmol) in a mixture of hydrochloric acid (20 mL of a 5N solution) and acetonitrile (15 mL) was stirred at room temperature for 96 hours. The resulting suspension was then concentrated and filtered, and the resulting solid dried in vacuo over P2O5 to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=4.54 min, MH+ 386].

후처리

  1. concentrationThe resulting suspension was then concentrated
  2. filtrationfiltered
  3. dry with materialthe resulting solid dried in vacuo over P2O5

출처 및 근거

ORD 기록
ord-f9b0c7b06eb24f1eb2fd79362adec46b
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003806B2

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