Hydrochloric Acid → 1-(2,2-Difluoroethyl)piperidin-4-amine Dihydrochloride
반응식
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([F:17])[F:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[ClH:19].[F:17][CH:15]([F:16])[CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1참가 물질
4
실험 절차
To a cooled (0 degrees) mixture of 1.21 g (4.58 mmole) of [1-(2,2-difluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 20 mL of dioxane, was added 5.7 mL of 4M HCl in dioxane. The mixture was stirred at room temperature overnight, and the solid collected by filtration to give 0.90 g of 1-(2,2-difluoro-ethyl)-piperidin-4-ylamine dihydrochloride.
후처리
- temperatureTo a cooled
- filtrationthe solid collected by filtration
출처 및 근거
- ORD 기록
- ord-e09a25ffa64343cc9ed69e9edec03e59
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003785B2
반응 노트
불러오는 중…