Hydrochloric Acid → 1-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

HRID 1676526노트

반응식

HRID 1676526 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH2:10][CH2:9]1)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[CH3:20][S:17]([CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)(=[O:19])=[O:18]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67355480[1-(3-Methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

생성물 1

HCID 673553041-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a cooled (0 degrees) mixture of 3.6 g (0.0113 mole) of [1-(3-methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 30 mL of dioxane, was added 14.1 mL of 4M HCl in dioxane. The mixture was stirred 18 hours at room temperature, and the solid collected by filtration to give 2.3 g of 1-(3-methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride.

후처리

  1. temperatureTo a cooled
  2. filtrationthe solid collected by filtration

출처 및 근거

ORD 기록
ord-7c4232b425dd4a1f8999d9e3ac9d02d4
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003785B2

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