Lithium Hydroxide → 3-Isopropoxy-4-nitrobenzoic acid

HRID 1676532

반응식

HRID 1676532 반응식
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([O:13][CH:14]([CH3:16])[CH3:15])[CH:5]=1.[OH-].[Li+]>CO>[CH:14]([O:13][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[N+:10]([O-:12])=[O:11])[C:3]([OH:17])=[O:2])([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 21187964Methyl 3-isopropoxy-4-nitrobenzoate

생성물 1

HCID 6029283-Isopropoxy-4-nitrobenzoic acid수율 0.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1.0 g (4.2 mole) of 3-isopropoxy-4-nitro-benzoic acid methyl ester in 20 mL of methanol was added 8.4 mL (8.4 mole) of 1M lithium hydroxide. The mixture was stirred at room temperature for 2 hours. The mixture was partially concentrated under reduced pressure and then acidified to by addition of 1 M of hydrochloric acid. The solid, which formed, was collected by filtration, washed with water and dried under vacuum to give 0.93 g of 3-isopropoxy-4-nitro-benzoic acid as a white solid.

후처리

  1. concentrationThe mixture was partially concentrated under reduced pressure
  2. additionacidified to by addition of 1 M of hydrochloric acid
  3. customThe solid, which formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-757f21fd13ab4c81ae355543d164fc48
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003785B2

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