Furosemide → Benzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate

HRID 1676930

반응식

HRID 1676930 반응식
[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:10]([Cl:21])[CH:9]=2)[O:4][CH:5]=1.[CH2:22](Cl)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>CN(C=O)C>[NH2:20][S:17]([C:11]1[C:10]([Cl:21])=[CH:9][C:8]([NH:7][CH2:6][C:3]2[O:4][CH:5]=[CH:1][CH:2]=2)=[C:13]([CH:12]=1)[C:14]([O:16][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:15])(=[O:19])=[O:18]

참가 물질

4

반응물 2

HCID 3440FurosemideHCID 7503Benzyl Chloride

생성물 1

HCID 11697463Benzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In a similar manner to Example 3, furosemide can be reacted with benzyl chloride in DMF to yield benzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate.

출처 및 근거

ORD 기록
ord-0728766472e54d80aa3b9252f0cc9871
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008283B2

연결된 노트

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